alt.hn

7/22/2026 at 3:45:18 PM

Does creatine make you smarter?

 https://dynomight.net/creatine/

by surprisetalk

7/22/2026 at 4:01:58 PM

Good discussion, but this conclusion:

> I don’t know. Maybe a little.

is not the right way to interpret the null result (insufficient evidence to reject null hypothesis that it has no effect) because the prior for supplements that people are trying to sell you is so low. In the absence of clear, strong evidence, you should assume the the whole thing is just an example of motivated reasoning. People want nootropics to be real, and other people really want to sell you readily available powders by claiming they have nootropic properties. In that environment, they were always going to trying to concoct a similar narrative about some supplement, and it just happened to be creatine. Those efforts were always going to result in a handful of "positive" studies that turn out to be non-reproducible, maybe because of p-hacking, maybe because of publication bias, maybe because of outright fraud. This is what the literature always looks like for stuff that just doesn't work. If it did work - if the effect size was large enough that you could personally detect it in your own life - then the papers would be trying to put error bars around the effect size, not trying (and failing) to barely distinguish it from a placebo.

“If your experiment needs statistics, you ought to have done a better experiment.” - Ernest Rutherford

by olooney

7/22/2026 at 4:47:36 PM

I think this is quite different because (1) creatine has been proven to be completely harmless for people of all ages absent some rare thing like a kidney disorder and (2) it has a bunch of clearly measurable positive effects.

So this is more like trying to determine whether ginseng is good at keeping away colds or whatever. Maybe it does (actually quickly searching this, it definitely does but let's pretend it's as folksy as it sounds for a minute) but even if it doesn't then it's harmless and has a bunch of other effects, so when one takes it - the whole possible cold prophylaxis can just be seen as an added perk.

by somenameforme

7/22/2026 at 7:57:35 PM

Issue being that if you took everything that's "probably harmless" at once, cramming your body full of supplements, you might just end up harming yourself with substances that are toxic above certain amounts (acute iron toxicity etc.). Also the more random stuff you take, the more likely it is that something you took actually does turn out to have been harmful later.

So no, you should not take something merely because it's "probably harmless".

by chmod775

7/22/2026 at 8:48:29 PM

You are strawmanning what he said. What he said is much better summarized as if a substance has other beneficial effects and there is one that is potentially just placebo, then it is ok. That is completely different than your paraphrase.

by wuliwong

7/22/2026 at 7:52:39 PM

Is there a particular rare kidney disorder that creatine is contraindicated for? Because kidney disease is not rare, something like 14% of US adults have kidney disease.

by zardo

7/22/2026 at 5:01:29 PM

and the thing people seem to not understand: how exactly do you _expect_ to be able to notice this change? Its something that happens after you take it for a prolonged period of time (>7days) and only has a minor/medium effect.

It doesn't make you a genius. I think a better view on it is that it may mitigate some of the adhs symptoms (at least for me).

I can keep on track for a significantly longer time since ive started supplementing with it at ~15g/day - and while i dont feel a difference, i can observe it when actually paying attention to what i do / how often i drift off etc.

by ffsm8

7/22/2026 at 4:37:35 PM

What I'm getting from all this is that we have an armchair expert explaining details about something they're not an expert in, and we have you reviewing the way they present this information, saying their very weak hedge wasn't strongly negative enough. Based on priors about the industry.

Basically, HN doing HN things - having a good deep think about topics outside their realm of expertise, then debating the minutiae. I'd just rather trust someone who has spent their career researching this stuff, thanks (unless that's what you do - in which case please tell us more).

by switchbak

7/22/2026 at 8:22:22 PM

"HN doing HN things" over someone saying "good discussion, however, one point about the conclusion" and having that point be very rational and still open to debate.

Is discussing such secondary but still highly relevant aspects verboten? Must every comment here be by a lead researcher in the specific field? Would a biomedical science researcher necessarily have any more expertise on these important secondary aspects?

"Trust me, I'm a scientitian". No thanks.

by dundarious

7/22/2026 at 4:50:11 PM

It may be minutiae, but olooney’s point is valid: the evidence doesn’t seem to support saying “maybe a little”. Remove that statement from the conclusion and it’s on the right track, aside from the arbitrary IQ point calculation which is nonsensical.

by antonvs

7/22/2026 at 4:10:40 PM

If you're being academically rigorous about it, sure, but I think it's fine as an informal conclusion.

by Retr0id

7/22/2026 at 4:20:03 PM

Even as an informal conclusion I think it's important to know who you're up against and what their motivations are. Waving that away is how we get people like known, obvious charlatans like RFK Jr in any sort of position of power. I know this is nitpicking word choice but the informal conclusion is "Not likely, and not enough to matter for anything."

by jdiff

7/22/2026 at 4:25:05 PM

Personally I take creatine for entirely non-cognitive reasons, so it's reassuring to know it's probably not making me any dumber.

by Retr0id

7/22/2026 at 4:37:43 PM

Though you also have to consider potentially adulterated powder (accidental or not) in the unregulated supplement industry.

That's why I dropped creatine since I didn't notice any benefits when I tried it for a year.

by hombre_fatal

7/22/2026 at 5:00:05 PM

With most industries companies live and die by their reputation. Find a bulk provider with a positive reputation and the creatine you buy is almost certainly going to be safer than e.g. eating at Taco Bell. And with creatine in particular it's so dirt cheap that a lot of motivation for dodgy stuff goes away unlike e.g. with protein powders where amino acid spiking can save a company a bunch of money. And incidentally creatine is one of the substances dodgy companies use for amino acid spiking, just because it's so cheap!

That said it's obviously the right decision to drop it if you're not seeing any effects. The interesting thing about creatine is that people's bodies are very different in their natural levels of creatine, and if you're already at 'saturation' then more creatine isn't going to do anything. Same reason the typical benefits of creatine don't show much difference beyond 5g/day. That's enough to send the overwhelming majority of people towards 'saturation.'

by somenameforme

7/22/2026 at 6:03:05 PM

There is a brand of creatine manufactured in the US (con-cret) and a brand manufactured in Germany (Creapure). Either of those companies should address the concern around adulterated powder.

> That's why I dropped creatine since I didn't notice any benefits when I tried it for a year.

Some percentage of people (~20%) are creatine non-responders [1]. It's pretty reasonable to try creatine and then drop it if you find no benefit. I personally find the gain very marginal.

[1] https://fitchef.com/shorts/creatine-non-responder/

by bhelkey

7/22/2026 at 8:05:56 PM

For me it has an insanely large effect. Roughly 30% more reps and endurance.

by econ

7/22/2026 at 8:38:45 PM

When I stopped taking it, I went from 12 reps to 10, and slower recovery.

My level at tennis dropped too, but bicycle endurance remained the same.

I stopped because of high blood creatinine, and wanted to see what baseline was

by zorobo

7/22/2026 at 4:31:59 PM

it might even be counteracting the negative effects of your frequent contact with airborne nitrogen

by NopIdoN

7/22/2026 at 8:23:17 PM

what negative effects? N2 is inert under physiological conditions.

by infinite_spin

7/22/2026 at 4:26:01 PM

What value is there to an informal conclusion when the topic is as important as intelligence? The downsides to creatine if taken without good scientific backing should not be disregarded, yet that’s exactly what many ordinary people are now doing because of “informal conclusions” like this.

by ttul

7/22/2026 at 4:28:19 PM

Are there really downsides to creatine though? (Genuine question). All the advice I've seen makes it seem like it's basically just good for you even if it doesn't accomplish some specific thing. The only downside I've heard is maybe water retention?

by overgard

7/22/2026 at 4:29:06 PM

What are the "downsides"? It is one of the most studied substances and except in special cases like kidney issues it is totally safe.

by freehorse

7/22/2026 at 4:47:42 PM

The null is surely different in this case because we know that supplemented creatine goes to the brain and the brain uses it, which is definitely not a claim all supplements can make.

The fact that there's a biologically plausible mechanism plus mixed statistical evidence makes "maybe" a perfectly reasonable conclusion.

by artrockalter

7/22/2026 at 7:28:05 PM

You are essentially trying to say that most studies regarding supplements are not valid

by Ker102

7/22/2026 at 7:37:19 PM

I think the way you interpret the null result is downstream of considering creatine as "a supplement". You can make the null result say anything by changing your prior about creatine or supplements. That's the issue with priors.

You also seem to reject the possibility that some things help just a bit. The author has another article in the same vein about "things that can help maybe a bit but the evidence we have doesn't really help detecting small effects" https://dynomight.net/vitamin-d/

by Zababa

7/22/2026 at 4:27:55 PM

mandatory XKCD https://xkcd.com/882/ "Jellybeans cause acne"

by abirch

7/22/2026 at 4:37:12 PM

I was visiting a friend’s lab at NASA Ames the other day. I smiled seeing this on the wall there. I sometimes daydream about what it’d be like if our primary education system devoted an hour a week to reading / discussing comics (well, XKCD specifically), or pages form What If…? Maybe it’d kill the magic of it, but I still feel plenty of seeds would get planted along the way for more critical thinking later in life.

by mrexroad

7/22/2026 at 8:04:31 PM

Just the green ones. If they found a link, they found a link

I'm sure that the comic wants to be sarcastic but is missing the mark here. This is how science works. Trying and failing every color except green, does not mean that the green experiment has an invalid result.

The author is not understanding that each experiment is independent.

The correct cartoon should show researchers trying green jellybeans 100 times and finding that the experiment gives a positive result one and a negative result 99 times, and then the press keeping only the positive result (Or this comic, but saying that all jellybeans produce acne).

Mocking the scientific method, and showing scientists as lazy people that play video-games all day is funny, but people should not take this as god's speech without any critical thinking. This in your workplace says "I don't really understand statistics" to me.

There is an effect that is statistically rare just by chance, AND is consistently absent within a huge control group of "non-green jellybeans" (the author seems to think that this weakens the result, but in fact is reinforcing it). And it needs further research. Not less, not more.

by pvaldes

7/22/2026 at 4:05:32 PM

Heavily agreed. The supplement industry has such a low level of reliability that it has really soured me on so many practices people have. And I flat out do not understand how some of the supplement stores survive.

by taeric

7/22/2026 at 4:16:18 PM

Hard sell. I remember the time I went to GNC and they gave me a free sample of the notorious Jack3D which had some kind of amphetamine-like stimulant in it and was associated with young soldiers in the US Army falling down dead.

by PaulHoule

7/22/2026 at 4:57:45 PM

They survive because people want to believe. Look at the history: the phrase “snake oil” exists because people actually sold products by that name as a remedy. There were also tonics based on radium.

“There's a sucker born every minute.”

by antonvs

7/22/2026 at 5:34:38 PM

The story of how the phrase snake oil came to be is a fascinating one. Clark Stanley, an American, ripped off a Chinese product which was actually a decent anti-inflammatory, and didn't put any snake oil in his snake oil, which is why it didn't work!

by fragmede

7/22/2026 at 4:33:31 PM

>And I flat out do not understand how some of the supplement stores survive.

I think mostly through placebo effect, people buy a supplement to treat condition X and they think it's getting better, so they keep buying.

I mean, just look at the wide variety of homeopathic "cures" that are often so diluted that there might not be any molecules of the active ingredient left. Yet people keep buying it.

by Johnny555

7/22/2026 at 4:10:23 PM

Okay, but it kind of sounds like you want to nanny-state the writer's language.

Their conclusion seems like an absolutely fair interpretation of what they saw, and it also strikes me as dangerous -- perhaps more dangerous -- to suggest "writer genuinely believes, or doesn't believe, a thing, but they should say it differently from their own interpretation because..people are dumb?" Something like that.

by jrm4

7/22/2026 at 4:26:18 PM

One person is not a nation.

by jdiff

7/22/2026 at 4:48:21 PM

I have severe sleep apnea as well as insomnia. I may also be a multi-phasic sleeper. In any case my average sleep per night is ~3.5 hours with only ~1.5 hours of deep sleep. I use light therapy, CPAP, medications, etc but none of it solves my problems. I started taking creatine daily a couple of months ago. I've noticed a significant uptick in my cognitive abilities, despite being constantly sleep deprived. TFA doesn't touch on this apparent benefit of creatine, so thought I'd mention it for others who might be suffering from similar sleep issues.

by block_dagger

7/22/2026 at 8:47:54 PM

For sleep apnea you may look into playing the didgeridoo for 30 minutes a day. The circular breathing every day really improve people's symptoms, and I've heard you see results after a few weeks or months. I'm in the middle of trying this but unfortunately I just haven't been doing it every day.

I've also heard just practicing circular breathing by blowing through a straw into a cup of water can produce the same effect but playing a didge is just so much cooler.

by helterskelter

7/22/2026 at 8:42:49 PM

There was actually a VERY recent study on mega-dose creatine for sleep deprivation:

  > "Single dose creatine improves cognitive performance and induces changes in cerebral high energy phosphates during sleep deprivation"
https://www.nature.com/articles/s41598-024-54249-9

You need a dose high enough to penetrate the blood-brain barrier, around 0.3g/kg (so ~30g for a 100kg person).

by gavinray

7/22/2026 at 8:45:14 PM

Last year, I was severely sleep deprived, but needed to focus. On a whim, I took 25 grams of micronized creatine and it removed the issue with the dampened cognitive abilities. It just worked. It's nothing I would recommend as a long-term solution to sleep problems, but as a possible solution in a pinch, it could work.

by tyjen

7/22/2026 at 7:58:05 PM

Apnea sufferer here, for whom cpap stopped working after weight loss. It turned out that my mouth was opening during sleep, reducing the effectiveness of cpap, and after adding a chin strap to keep my mouth shut I have had very few apnea events.

The mouth-tapers aren’t always wrong (though we do always look silly).

by threecheese

7/22/2026 at 7:46:27 PM

I also started sleeping measurably better when I started taking creatine, but the broader evidence strongly suggests this was some kind of coincidence

by mgraczyk

7/22/2026 at 7:52:24 PM

What dosage are we talking here?

by boringg

7/22/2026 at 7:57:00 PM

5g/day

by mgraczyk

7/22/2026 at 8:14:50 PM

I take 5g/day, through better part of last 9-12 months (don't remember when I started).

No noticeable cognitive difference/improvement. And the more I've researched creatine the less convinced I am that there are reliable conclusions about cognitive impacts.

Significant physical changes! But other than the pure aesthetics, it's hard to say that my strength increases are tied to creatine or instead a solid routine, plan, diet, and progressive overload. Probably some all of above.

I also take whey protein isolate (20-25g at least once a day)

The Nootropic space fascinates me. A few observations:

- Not sure if caffeine is considered nootropic. Caffeine definitely makes a difference.

- Unclear if placebo effect or real, L-theanine seems to help with calm and focus.

- Otherwise, when it comes to what I'm sure alters my state/body/etc. - drugs! And I'm not suggesting anything specific but my point is the effects are obvious/real/etc. vs. much of the supplement space that suffers from very murky conclusions (imo).

by grvdrm

7/22/2026 at 8:20:01 PM

Im curious, since I don’t drink coffee nor take protein supplements and the like, my question is: is the plan you keep taking what you take, let’s say, “forever”? Because the moment you stop taking, wouldn’t you notice a big drop?

by sdevonoes

7/22/2026 at 8:38:37 PM

> Because the moment you stop taking, wouldn’t you notice a big drop?

No. They're not steroids.

by 0xmattf

7/22/2026 at 8:48:48 PM

Well, for caffeine you might... at least in the short term.

But to be more specific:

* Protein supplements make it easier for your body to get the protein required for whatever demand you're putting on it. You need higher protein intake to growth than to sustain muscle. If you were on protein supplementation during a growth phase, and then transitioned to a maintain, and stopped supplementing, while making sure your actual diet was sufficient, then you could in principle maintain your muscle mass with no problem. The extrapolation of this is that in principle, you could always replace protein supplements with "real food", regardless of phase and get pretty much the same benefits. There may be lifestyle/ease/cost tradeoffs.

* Creatine supplementation helps your body get "a little extra" work done. The direct boost that creatine grants you is real, but also like... small. I think it's often visualized as "it helps you get that one extra rep/half rep". Where creatine pays off is that by sustainably helping you get that one extra rep, it helps create greater demand on your body over time, therefore promoting more growth. If you stopped creatine supplementation, you would probably lose that "extra rep", but all the extra growth that you got would be locked in.

* Caffeine... well, that's far more psychological. Leaving the world of sports, as a knowledge worker, I've committed myself to my addiction. The withdrawal is real, and even if I worked through the headache, I definitely do not feel as sharp.

by icegreentea2

7/22/2026 at 4:06:04 PM

Sometimes I stay up until 1–3 a.m. because I'm working on a problem that's so interesting I can't stop until I make progress.

If I know I'm only going to get a few hours of sleep, I'll take 5–10 g of creatine, drink plenty of water, and go to bed. The next morning, I usually don't wake up with a headache.

If I skip the creatine under the same conditions, I'm much more likely to wake up with a headache after a short night's sleep.

Now it's become a habit, I automatically take creatine whenever I know my sleep duration is going to be much shorter than usual.

by faangguyindia

7/22/2026 at 4:11:30 PM

Do you still drink water when you skip creatine? Being dehydrated causes headaches, so it may be the extra water intake that's helping and not the creatine.

by johnthedebs

7/22/2026 at 4:16:31 PM

yes, i always drink plenty of water throughout day and night too, infact when i get stuck on a problem i go for a walk and drink water.

So drinking water part is consistent with or without creatine. I do know the creatine takes a while to build up, so i don't know why it works but it does.

by faangguyindia

7/22/2026 at 8:45:26 PM

I do the same thing with pickle juice. Works for me.

by _superposition_

7/22/2026 at 4:09:28 PM

> If I know I'm only going to get a few hours of sleep, I'll ... drink plenty of water

https://my.clevelandclinic.org/health/diseases/21517-dehydra...

by BugsJustFindMe

7/22/2026 at 4:17:48 PM

from your link

>Headache pain often appears along with other signs and symptoms of dehydration, including darker-than-usual pee, dry mouth and fatigue

none of these symptoms are true for me.

by faangguyindia

7/22/2026 at 4:21:12 PM

"often" and "always" are two different words that mean two different things

by BugsJustFindMe

7/22/2026 at 4:25:56 PM

Yes, but hydration isn’t really a problem for me. I’m a bit of a water purification nerd, I collect water from a natural waterfall, run it through multiple stages of purification, and then start convincing myself it has some magical properties. I don’t drink soda or caffeine, I mostly just drink water.

by faangguyindia

7/22/2026 at 4:08:17 PM

Do you take monohydrate or HCL?

by pawelduda

7/22/2026 at 7:29:30 PM

Monihydrate causes me terrible GI issues and insomnia. I’ve found HCL to me much easier on my body.

by SkyPuncher

7/22/2026 at 4:18:02 PM

most common one, monohydrate.

by faangguyindia

7/22/2026 at 4:10:08 PM

Most people taking creatine just need to drink water. They drink more water using creatine. In reality, the water/hydration is doing the heaviest lift, not the creatine.

by John23832

7/22/2026 at 4:59:45 PM

I was taking 5mg of Creatine and was in the ER for an unrelated reason. My metabolic panel measured creatinine at 1.34 mg/dL. A panel from last year without the supplement was a very normal 0.95. These were gummies and I wasn’t slamming water.

BTW, it tends to trash the eGFR test which relies on an unbiased creatinine reading.

by CalChris

7/22/2026 at 4:17:25 PM

I don’t know. I personally wouldn’t take it if you aren’t also working out/lifting frequently (even if you drink a ton of water).

Anecdotal so safe to ignore this… but my hair did thin out but only after I was lazier on my work outs. Stopped taking and hair mostly returned to normal thank God.

by TIPSIO

7/22/2026 at 8:42:52 PM

> but my hair did thin out but only after I was lazier on my work outs.

How old are you?

Also, working out helps reduce stress. Does it seem more plausible that getting lazier on your workouts, rather than the creatine, increased stress in your life, thus the hair thinning?

I have never heard of creatine causing thinning hair.

by 0xmattf

7/22/2026 at 4:20:23 PM

I get severe muscle cramping, even after pounding water and electrolytes. Like I can’t handle my kid something in the car without risking a spasm.

by leoqa

7/22/2026 at 8:48:05 PM

Antacids did this to me. I was convinced it was electrolytes, would take supps etc but I believe it came down to calcium absorption. Taking a break from the antacids immediately stopped the cramping.

by _superposition_

7/22/2026 at 4:45:27 PM

Do you lift weights?

by matwood

7/22/2026 at 5:58:44 PM

Yes I’m fit, easily passed military and LEO fitness tests this year.

by leoqa

7/22/2026 at 7:30:53 PM

The reason I asked is that creatine will allow you to lift a bit more (a little more weight, a few more reps). This will cause more muscle fatigue which in turn can lead to more cramping. Water and electrolytes can help, but when the muscles are fatigued they are still more likely to cramp.

by matwood

7/22/2026 at 4:23:57 PM

spasms are commonly a potassium deficiency, you could take a multivitamin.

by logicallee

7/22/2026 at 4:47:08 PM

Multivitamins don't contain a lot of potassium because of the risk over overdosing in that form. Eat a banana instead (or 3).

by smallerize

7/22/2026 at 5:59:18 PM

I do function health and have completely normal nutrient blood levels.

by leoqa

7/22/2026 at 4:24:59 PM

I like creatine when I’m lifting because it reduces soreness. For some people that effect helps them push further and train harder, for me it’s just proactive pain relief

by parpfish

7/22/2026 at 4:53:14 PM

Plausible-sounding mechanisms like you're presenting here do not add value to the discourse without data. There are tons of plausible mechanisms we could make up absent empirical evidence to distinguish them.

by kixiQu

7/22/2026 at 5:37:13 PM

You’re yelling at clouds.

by John23832

7/22/2026 at 8:08:14 PM

Clouds of intracellular water more efficiently retained in muscle due to creatine supplementation[?]. Hydration is controlled for in some studies but not all.

by kekebo

7/22/2026 at 4:16:39 PM

A pity that water isn’t being sold as an expensive supplement. Or is it?

by Isamu

7/22/2026 at 4:21:19 PM

There are lots like Vitamin water, alkaline, and coconut water. And overpriced salt packets like Nuun and LMNT.

There's also no shortage of expensive water bottles being sold, and smart water bottles that track your drinking frequencies and flavor pods sold via subscription.

by jerlam

7/22/2026 at 4:46:22 PM

To go off topic a bit further, I recently went into Walgreens to buy some bottled water, and other than Evian, it was all advertised as alkaline. Is that just a trend, was it already alkaline and now that’s just in fashion? Personally I see it and worry I’ll get an upset stomach if it start messing with my pH.

by andy99

7/22/2026 at 5:29:13 PM

Water that's coming out of your tap is generally aiming for neutral (~7 ph). The alkaline waters in the store are using minerals to elevate it into probably the 9s.

Like many hippie health trends that then go mainstream, a lot of it seems to filter in from Rastafarian traditions, where in the Ital diet they believe that alkaline water coming from the Blue Mountains in Jamaica (and other natural springs there which are naturally alkaline) help detoxify the acids in the body.

by throwforfeds

7/22/2026 at 4:44:17 PM

I do really love LMNT, it's basically the only one I've tried that actually has a sizable dose of sodium, has no sugar, and tastes good.

by rhinoceraptor

7/22/2026 at 4:18:28 PM

You're looking in the wrong place. There is a moderately large industry around water bottles.

by geophile

7/22/2026 at 4:33:36 PM

I slam a lot of water. I also have a toddler and baby who suck at sleeping (I've done all the things, these kids just suck at sleeping).

Since taking creatine I feel so much more energized. I can make it through the day with just 2 coffees (was previously drinking 5 coffees and an energy drink).

Maybe it's placebo. Maybe it's not. I don't really care. I feel the benefit and I love it.

by richardlblair

7/22/2026 at 5:20:52 PM

I also drink a lot of water (always have). I also train Muay Thai and am in my 40s, which means an hour of 1:1 with my trainer would just leave me ridiculously tired. I started supplementing with creatine and immediately it was evident that it was working -- after 8-10 rounds on pads and the heavy bag I was fine. To the point where my trainer would often tell me to take another round on the bag.

At a certain point I was wondering if it was just placebo, stopped taking it for a month or so, and was quickly back to feeling tired after training. Started taking it again, back to feeling energized. It really does work.

by throwforfeds

7/22/2026 at 4:39:59 PM

"Creatine found to improve cognitive performance during sleep deprivation" (2024, 56 comments)

https://news.ycombinator.com/item?id=40170474

by jerlam

7/22/2026 at 4:54:55 PM

https://news.ycombinator.com/item?id=40184046

"Other studies already proved those effects with creatine with a normal dose schedule, what they were testing is if a single high dose would have a beneficial effect too, which it did. A normal schedule is 3-5g per day with an optional loading phase of 10-20g per day during 7 days.

In the study they used a single dose of 0.35g/kg which means 20-40g per dose. How do they not get diarrhea? The loading phase is usually split into several doses to avoid diarrhea and I can personally attest to that being a good idea."

What the above doesn't tell you is that taking a loading dose can draw water into your intestines causing diarrhea. You probably can guess how I found this out.

by richardlblair

7/22/2026 at 4:14:44 PM

I take my creatine with as little volume of water as possible, probably less than 50ml. I doubt that 50ml is having much impact on my overall hydration.

by Retr0id

7/22/2026 at 4:17:01 PM

How much water are you drinking the rest of the day? Creatine in theory makes you more thirsty such that you should be drinking more water throughout the day

by clayhacks

7/22/2026 at 4:18:31 PM

It's not something I track, but if it is making me thirstier then that sounds like another useful benefit.

by Retr0id

7/22/2026 at 4:20:05 PM

yes but again, the idea is that it helps retains water in your muscles so I don't see it aiding in regular water intake

by berkeatac

7/22/2026 at 4:17:25 PM

If you actually drank enough water daily, sans creatine, I'm sure you'd feel better.

by John23832

7/22/2026 at 4:20:51 PM

Hydration is important so I'm with you on the first half, but what is the proposed link between reduced creatine intake and emotional wellbeing?

by Retr0id

7/22/2026 at 4:22:44 PM

Placebo.

by John23832

7/22/2026 at 4:25:45 PM

I wasn't expecting creatine to have any bearing on my emotional state in the first place, so I'm not sure how that would work.

by Retr0id

7/22/2026 at 4:45:02 PM

Knowledge of the potential is peripheral expectation.

If you can say "Oh yea that makes sense" with the same set of knowledge you had both before and after some event happens, all else being equal, you have an expectation. That is enough for placebo.

You have to have literally 0 knowledge about an event to rule out placebo.

by John23832

7/22/2026 at 6:24:51 PM

Are you suggesting that the placebo effect applies retroactively? I'd been using creatine for months before I even heard there were conversations about supposed cognitive effects (and I hadn't noticed any myself, either, and I continue to not notice any. That isn't why I take it.)

by Retr0id

7/22/2026 at 4:59:09 PM

Why are you so sure that the poster (or anyone else commenting here) isn’t drinking enough water?

I drink lots of water. Lots and lots, to the point that it’s already kind of annoying how frequently I have to piss. I’m fairly skeptical that drinking yet more would yield any benefits.

by SubmarineClub

7/22/2026 at 4:26:15 PM

This is not true. Did you read the article?

by jgbuddy

7/22/2026 at 4:33:01 PM

People love to float this myth that everyone's just walking around dehydrated all the time and they do so based on absolutely no data.

by peder

7/22/2026 at 4:52:24 PM

Yes. None of the supposed action of creatine was backed by any statistically significant study. Just drink water. Or don't. It's up to you.

by John23832

7/22/2026 at 4:57:43 PM

Does creatine make you stronger?

Yes. It’s very rare for a supplement to have such strong and consistent evidence.

A widely-cited review says that short-term supplementation increases maximal power/strength by 5-15%. This in turn may increase the long-term gainz from strength-training exercise. Creatine also increases sprint performance by 1-5%. Though, there seems to be little if any benefit for endurance exercise like long-distance running.

https://pmc.ncbi.nlm.nih.gov/articles/PMC5469049/#CR46

by jgbuddy

7/22/2026 at 4:27:40 PM

just reminded me to buy a decent waterbottle - thank you

by jacob_rezi

7/22/2026 at 7:26:46 PM

I wonder if there’s any long term studies like how the body gets adjusted to creatine. Because human body is remarkable at adjusting and setting new baselines and I wonder if it’s true with creatine as well, like to have the same effect you need to take more creatine the longer you keep on taking it

by sajithdilshan

7/22/2026 at 4:22:35 PM

>Contrary to the common myth, thinking hard does not burn significantly more calories. (Demonstration: Start thinking hard, and watch as your heart rate does not increase.)

this is wrong [0] , it's just hard to measure.

[0]: https://pubmed.ncbi.nlm.nih.gov/32314956/

by serf

7/22/2026 at 4:31:51 PM

The original claim is not wrong. Thinking hard does not burn significantly more calories.

If it’s really hard to measure because the amount is so small that it requires precise equipment, it’s not significant relative to the rest of the body’s energy expenditure.

by Aurornis

7/22/2026 at 4:20:36 PM

This matches what Gwern wrote years ago [0]. It does unequivocally make you stronger though. So if you're training anyway, may as well take it and hope it makes you smarter as well (just believing might be enough for that sweet placebo effect).

[0] https://gwern.net/creatine

by doix

7/22/2026 at 4:06:31 PM

This made me wonder if sun exposure/vitamin D has any impact on storing or processing creatine, and maybe that's why the results in Australia were so much greater

by imzadi

7/22/2026 at 6:18:51 PM

I have definitely noticed improvements taking a larger dose with my energy when low on sleep, check out McMorris et al. (2006) which is not cited here. I agree it probably doesn't make you generally more 'smart' but it does may improve function under stress, e.g. when sleep deprived, also see Gordji-Nejad et al. (2024). I think the sleep benefits should at least be mentioned in this article.

Also search for 'sleep' in this comment section, seems many see similar improvements!

by jgbuddy

7/22/2026 at 4:53:22 PM

> Wikipedia quotes a paper saying people make / recycle around 50 kilograms per day. That would imply that people make around 0.5787 grams per second. But this is in tension with the idea that people use 100 watts at rest. Since that 100 watt number seems to be more strongly established, I think 1 gram per second is a better estimate.

The cited paper in Wikipedia might be accurate and the author is just expecting "at rest" to mean awake but mostly idle. I'd wager that during sleep, we use less than 100W. For the sake of argument if you take out 8 hours (asleep time) from a 24 hour period, you end up with a rate of ~0.8681 grams per second, much closer to 1g/s. Anyway, just a little fun with numbers.

by jermberj

7/22/2026 at 4:09:14 PM

In my experience, it wont make you smarter but my brain just feels more energized to think.

by bassiee

7/22/2026 at 4:15:35 PM

> Available short and long-term studies in healthy and diseased populations, from > infants to the elderly, at dosages ranging from 0.3 to 0.8 g/kg/day for up to 5 > years have consistently shown that creatine supplementation poses no adverse > health risks and may provide a number of health and performance benefits.

They missed a zero behind the comma, didn't they?

by sspehr

7/22/2026 at 4:36:14 PM

Likely. I did one time a creatine loading week of 30gr a day at 100kg body weight and I had to drink 7L of water to not feel like I have a hangover.

by jefozabuss

7/22/2026 at 4:02:26 PM

Studies I read seems to show a marginal boost in cognitionl and memory, but only if you were otherwise overtaxed for some reason.

Like being tired, stressed, etc...

by aeonik

7/22/2026 at 4:55:49 PM

Personally I have noticed a lot less cognitive impairment after a poor night’s sleep since starting on 10g per day. It seems to make a noticeable difference in my ability to reason and to act having slept less than 7 hours per night, even on consecutive nights.

by zemvpferreira

7/22/2026 at 4:32:45 PM

> thinking hard does not burn significantly more calories

Up to 50 Cal extra over ~2 hours of intense thinking IS significant given brains consume 240-400 Cal over 24 hours.

> Start thinking hard, and watch as your heart rate does not increase.

And yet you soon get tired and slow down. Now try the opposite. Stretch or punch the air a few times to get the heart rate going. You'll sustain brain performance for longer. Try it.

Perhaps the problem is that higher brain activity SHOULD trigger heart rate increase, but doesn't due to one of many design defects of the human body.

by MadameMinty

7/22/2026 at 5:00:33 PM

> Maybe for some reason, Rae et al.’s cohort had lower baseline creatine levels?

Well, yes. It is well known that you must eat fish, beef, i.e., animal protein, to get close to optimal levels of creatine.

by blueSky1989

7/22/2026 at 6:46:33 PM

Dang, missed opportunity to explain the actin-myosine sliding filament theory.

by odinthedog

7/22/2026 at 4:04:04 PM

I started taking 5g for cognition. Never any clear signal for that, but it does seem to help a bit with my (more than occasional) sleep deprivation. Mostly with fighting off headaches.

by softbuilder

7/22/2026 at 8:07:12 PM

> This in turn may increase the long-term gainz from strength-training exercise

Why is "gains" spelled this way? I found myself suddenly trusting the whole thing a little less. But maybe I'm missing something. Is this jargon in the body building world or something? Author being cheeky?

by eduction

7/22/2026 at 4:30:23 PM

Okay, I skimmed the article.

Is creatine safe to supplement for children?

by blobbers

7/22/2026 at 5:43:41 PM

Its something you might aswell just take, no proven side negative side effects, unless you are gulping it, it will benefit you

by Ker102

7/22/2026 at 4:11:45 PM

Why is creatine so popular lately? what changed?

by 6thbit

7/22/2026 at 4:14:41 PM

It’s always been popular among athletes and weight lifters but now nootropic influencers have gotten ahold of it. It’s one of the few supplements with robust scientific evidence of a strong effect but that’s in athletic performance not nootropics.

by throwup238

7/22/2026 at 5:31:25 PM

and that scientific evidence is new? like a new study boosted this or just resurfacing?

by 6thbit

7/22/2026 at 8:31:31 PM

No, creatine has been studied for decades and it’s been part of fads before (I remember Mac making a joke about creatine shits in It’s Always Sunny in Philadelphia a decade ago).

It’s just resurfacing as a general health fad/marketing campaign.

by throwup238

7/22/2026 at 4:17:46 PM

another upside is its also hella cheap so its a very easy addin

by exhumet

7/22/2026 at 7:58:49 PM

JRE mentioned it several times recently, I imagine it could have spiked interest but overall it's been growing over the past decade because of the advances in fitness trackers, IMO. It's been very easy to see its effect with trackers measuring FTP and VO2max.

by pandaman

7/22/2026 at 4:34:54 PM

I've been taking 5g/creatine daily for nearly 30 years. In weightlifting circles it's always been popular because it's cheap and one of the few non-steroidal supplements that actually works.

by matwood

7/22/2026 at 4:13:21 PM

Health fads come and go

by gedy

7/22/2026 at 5:34:27 PM

Creatine is a health fad? No other supplement has been this widely-used for such a long time. It was considered safe and effective when I started using it 30 years ago. The benefits are/were well established, the mechanisms well-known, the safety is impeccable. If anything, it's the most well-established supplement on the market - the exact opposite of a fad!

by perrygeo

7/22/2026 at 6:38:54 PM

OP was asking why the attention now though specifically. I'm not calling it quackery, etc.

by gedy

7/22/2026 at 5:36:51 PM

I experienced dramatic and obvious hair loss in my late twenties after starting creatine supplementation. I'm talking hundreds of hairs coming out every shower. It stopped when I stopped creatine. No I didn't make any other changes in diet or lifestyle at the time. I hadn't even heard of the link before that. This is actually one of those things that made me start doubting "the science" in general because it's supposedly not true, but, it obviously is true for my head beyond a reasonable doubt.

by eudamoniac

7/22/2026 at 4:35:02 PM

I think another source of variation on the results is the actual nutritional intake of the subjects.

The vegan/vegetarian is a big spectrum. A vegetarian eating plenty of dairy products and eggs should in theory be much better creatine-equipped than a poor vegan student feeding on noodles and ketchup pastas. A lot of pseudo-meat for vegans are full of processed shit.

Confusion will be even higher if you include fish in the vegetarian diet, which is odd but some people do that.

Could the cognitive effect works in the case of creatine deficiency (vegan) and not in the case a vegetarian (low creatine but not deficient) ?

by 131012

7/22/2026 at 4:48:19 PM

> if you include fish in the vegetarian diet, which is odd but some people do that.

Meat Is Murder but Fish Is Justifiable Homicide.

by ErroneousBosh

7/22/2026 at 8:34:34 PM

It's OK to eat fish cause they don't have any feelings

- Something in the way, Nirvana

by dotcoma

7/22/2026 at 4:14:12 PM

Nope, but makes a producer's pocket heavier :D

by igor_nast

7/22/2026 at 4:27:49 PM

When you realize that, you got a little smarter

by croes

7/22/2026 at 4:48:49 PM

I just ordered some yesterday because I saw something that reminded what my friend said recently about it boosting cognition. Then this morning I saw it mentioned in some health segment on tv. Now I stumble upon this discussion. Hmmm.

by msie

7/22/2026 at 3:57:04 PM

I remember learning about Creatine as a weightlifting teen

I never ended up doing it because you had to cycle it, and it was just one more thing to track

Is it the same case in 2026? Is there a simple pill I can take?

by brcmthrowaway

7/22/2026 at 3:58:31 PM

You don't have to cycle it. You also don't need to load it (a marketing ploy to get you to buy more).

You can just take 3-5g daily.

by domhudson

7/22/2026 at 4:12:44 PM

Cycling is also a marketing ploy, since it makes it sound more like a PED and less like a compound found naturally in meat. It's the same reason people say they 'take' whey, when Miss Muffet simply ate it.

by windward

7/22/2026 at 4:29:02 PM

Cycling creatine was the guidance from the 90s. 5g/day and drink plenty of water is all you need to do.

by matwood

7/22/2026 at 7:28:44 PM

I don't ever remember needing or being advised to cycle it.

It was always start by 'loading' and then cruise at 5g. Of course GNC was filled with sugar filled "delivery" products like Celltech that claimed to forego any need for 'loading'.

by F7F7F7

7/22/2026 at 3:59:58 PM

I've never heard of cycling it. We're you a teen during the steroid arrival? Maybe people were confusing things. I've always just done 5mg a day, but now people are talking about taking mega doses of like 20-30mg a day, shrug

by btheconqueror

7/22/2026 at 4:06:04 PM

Creatine is dosed in grams not milligrams, otherwise your number are correct.

by nick__m

7/22/2026 at 4:34:00 PM

Homeopathic sports supplementation

by jdelfuego

7/22/2026 at 4:11:39 PM

Yes, they did, and many still do write it on the package, but it is, and always was a myth born God knows when out of precaution, because nobody really knows anything about how all this stuff really works now, and they did know even less than that 30 years ago. There never really was any evidence that you have to cycle it, and nobody (aside from the manufacturers) ever says it anymore. It makes about as much sense as cycling protein powder.

As for pills, yes, there is about every form of creatine supplement now, even chewing gum, but this is just dumb, how much of creatine do you think you can consume this way in a day?

by krick

7/22/2026 at 4:00:55 PM

That’s never been the case, you were getting bad information.

by solumunus

7/22/2026 at 4:30:51 PM

It was certainly the case that gym bros thought you had to cycle it. But you're right that this was never necessary.

by switchbak

7/22/2026 at 3:58:00 PM

[dead]

by Helloworldboy

7/22/2026 at 4:23:54 PM

if you are using to slim down it will hold on to water unless you are bulking i dont see creatine to be consumed regularly

if you truly want fuel for the brain nothing beats keto

by zuzululu

7/22/2026 at 4:01:32 PM

Saved you a click:

> Does creatine make you smarter?

> I don’t know. Maybe a little.

by garciasn

7/22/2026 at 8:38:48 PM

in other words, it doesn't do much of anything, similar to most powders, supplements, and minerals/vitamins

People are throwing away their money

by paulpauper

7/22/2026 at 4:17:34 PM

The conclusions aren't any different (it's one of the few thing that helps strength, poses no danger to your hair, and almost certainly does nothing for cognition), but the articles at https://www.strongerbyscience.com/?s=creatine are far more comprehensive, including the famous extremely long podcast episodes they used to do.

The one thing this misses is many supplements are tainted, which skews the popular perception of both upsides and risks. This was especially true in the US prior to 2005 or so when prohormones were still legal over the counter. Anything branded that wasn't just pure creatine was extremely likely to actually be a low-dose oral steroid, which really can make you lose hair and will increase strength quite a bit more than any dietary supplement.

This also misses caffeine as the other a-tier supplement that consistently shows strength increases in RCTs, though of course, caffeine is more frought than creatine because you build tolerance and it can disturb sleep.

by nonameiguess

7/22/2026 at 4:29:35 PM

"poses no danger to your hair" I keep hearing folks say this, and even in this thread there's someone who's experienced that and had it stop when they eliminated creatine. I too have experienced exactly that with exactly the stopping of issues once I stopped taking creatine.

Perhaps you can say "danger to your hair is rare", but there's very clearly (to me at least) an effect there, and the way it gets hand-waved away is strange to me.

by switchbak

7/22/2026 at 5:34:38 PM

> poses no danger to your hair,

Last I checked, the only study actually focusing on this is n=38, out of Iran, and has heavy conflict of interest issues (funded by the supplement industry).

That's not remotely sufficient to consider this a settled fact.

by volkl48

7/22/2026 at 6:43:18 PM

I feel like you would need to find some correlation between dosing creatine and increased DHT production to find a link between the two.

Creatine is not an anabolic steroid and does not increase testosterone levels, according to Harvard Health, so while there was 1 suspicious study that claimed that creatine increased DHT, that study has afterwards not been able to be replicated, and since creatine does not manipulate hormones but rather energy instead, it seems to as closes a possible to being a settled fact sans the final nail in the coffin.

by BizarroLand

7/22/2026 at 4:33:03 PM

> This also misses caffeine as the other a-tier supplement

In college Ripped Fuel wasn't banned yet. We would take two, go to the gym for 2 hours, shower, then go out until the sun came up the next day. It's no surprise it was eventually banned. I think some people ended up dying by taking too many.

by matwood

7/22/2026 at 4:18:11 PM

[dead]

by deton3991

7/22/2026 at 4:04:06 PM

Article's answer to its own question:

It safely builds muscle and boosts cognition.

by thisisauserid

7/22/2026 at 4:10:38 PM

No, it does not.

More like "probably", "yes", and "probably not."

by dd8601fn

7/22/2026 at 3:58:51 PM

I don’t think they’re strong evidence that it does anything beyond helping you build muscle. There are some people say they think clearer, but I don’t think that’s been measured in any significant way.

by dvduval

7/22/2026 at 5:01:58 PM

[dead]

by mikodin

7/22/2026 at 3:54:13 PM

Given LLM's is being smarter still a worthwhile to optimize with supplements?

by petra

7/22/2026 at 4:22:34 PM

Of course it is. LLMs aren't as smart as you think, or at least their "intelligence" isn't comparable to ours. They're just a useful tool, and they will always need someone to guide them.

by isakmarr

7/22/2026 at 4:43:05 PM

Yeah, mix some creatine in with the thermal paste. It should help!

by toast0

7/22/2026 at 3:57:43 PM

that was hard to parse, but yes, because then you can ask smarter questions to the LLM which saves you money, so you can afford supplements

by fragmede

7/22/2026 at 4:26:01 PM

Productivity isn’t the only reason to be smarter. For example, there’s also the benefit of asking fewer inane questions on the internet (hypothetically)

by binary132

7/22/2026 at 4:33:38 PM

Present company excluded, of course.

by shermantanktop

7/22/2026 at 6:37:03 PM

I still seek the fount of infinite wisdom.

by binary132

7/22/2026 at 4:31:46 PM

LoL.maybe the question is not phrased in the best way, English as a second language and laziness, but it's a pretty decent question.

by petra