alt.hn

6/23/2026 at 2:03:40 AM

Definium's LSD-based depression pill delivers strong late-stage results

 https://www.reuters.com/business/healthcare-pharmaceuticals/definiums-lsd-based-pill-reduces-depression-symptoms-late-stage-trial-2026-06-22/

by bushwart

6/23/2026 at 4:22:00 AM

How do you do a double-blind with a drug that perceptibly changes your state of mind?

by vortep

6/23/2026 at 8:09:23 AM

I guess you do it anyway? the change in the state of mind is thought to be at least in part the mechanism of action, no? so if thats what makes it work, its good to test it against a non hallucinogen

by RugnirViking

6/23/2026 at 8:32:20 AM

You can't, and it's a real problem for some people. Other people realize that, like testing the efficacy of parachutes by throwing two people off an airplane, one without a parachute; other people realize the double blind standard can't be applied but that the results aren't woo mystical astrology unfounded conclusions despite that.

by fragmede

6/23/2026 at 10:49:11 AM

academia is struggling to realize this

by thepotatodude

6/23/2026 at 3:12:18 AM

What is their dosing schedule? It says single dose, but how much are they giving?

by amanaplanacanal

6/23/2026 at 2:15:27 AM

pretty exciting if this passes FDA approval. it's getting close.

by andsoitis

6/23/2026 at 3:25:35 AM

I'm going to skip the line on this one.

by Acrobatic_Road

6/23/2026 at 7:22:02 AM

> Definium Therapeutics tab said a single dose of its LSD-based experimental pill significantly reduced symptoms of major depression

Reminds me of Soma from “brave new world” by aldus huxley.

We’re only missing a way to generate some pre-conditioned humans and we’re pretty much done (birthrates are already falling anyway, no need for malthusian practices).

by znpy

6/23/2026 at 8:26:43 AM

Do other antidepressants, of which there are many, remind you of Soma as well?

by fragmede

6/23/2026 at 4:37:56 AM

What happens if I take 10?

Oh wait. That layoff caused my health insurance to quit working.

Oh well, can’t have any fun these days.

by qsxfthnkp2322