alt.hn

2/23/2026 at 6:37:22 PM

Liver exerkine reverses Alzheimer's-related memory loss via vasculature

https://www.sciencedirect.com/science/article/pii/S009286742600111X

by PaulHoule

2/23/2026 at 10:14:48 PM

Blood factors transfer the benefits of exercise to the aged brain independent of physical activity. Here, we show that the liver-derived exercise factor (exerkine) glycosylphosphatidylinositol (GPI)-specific phospholipase D1 (GPLD1), a GPI-degrading enzyme, reverses aging- and Alzheimer's-related memory loss by targeting the brain vasculature.

https://pubmed.ncbi.nlm.nih.gov/41713415/

by m463

2/23/2026 at 7:07:52 PM

In mice.

by givemeethekeys

2/23/2026 at 10:45:33 PM

Appending [in mice] to relevant article titles honestly should be a site rule here. And we might also consider [with immunosuppressants].

by thomassmith65