Another factor was tech and crypto. The Biden administration was widely seen as hostile to crypto and DeFi, which turned off a lot of younger and online voters and created unexpected opposition to Harris.There was also a perception of politicization in agencies that are supposed to be neutral. People pointed to things like EV summits excluding Tesla, or regulatory pressure and delays affecting SpaceX launches and Tesla investigations. Whether justified or not, the optics made it look selective and punitive.
Individually these aren't huge voting blocs, but at the margins they likely added to the broader dissatisfaction.
And what also didn't help was the perception that the Harris campaign operated in something of an ideological bubble. For example, reports that staff discouraged her from doing a Joe Rogan interview because they disliked him reinforced the idea of an echo chamber, which ties into your point about trans issues.