12/28/2025 at 6:48:08 AM
> “This study shows that paternal exercise can confer benefits — enhanced endurance and metabolic health — to offspring,”So good habits can be good for offspring.
> For instance, mouse fathers exposed to nicotine(opens a new tab) sire male pups with livers that are good at disarming not just nicotine but cocaine and other toxins as well.
So bad habits can be good for offspring.
> “We just don’t have really any understanding of how RNAs can do this, and that’s the hand-wavy part,”
It seems to me to all be the handwavy part. I'm happy to wait until the research is considerably further advanced, past the clickbait stage.
by jibal
12/28/2025 at 8:30:34 AM
If you ignore "good" and "bad" then it's just "traits can be passed through this mechanism" egg seems a lot more reasonable.by AlecSchueler
12/28/2025 at 12:42:52 PM
But that's not what it says. RNA fragments are entering the ovum and having some sort of effect .... that's quite different from passing traits the way genes on chromosomes do.by jibal
12/28/2025 at 5:14:47 PM
But shouldn’t there have been an evolutionary advantage for such a thing to develop?by matt-attack
12/28/2025 at 7:02:58 PM
Not necessarily for the individual.Some trees have mechanisms, for instance, where they die quickly but signal other trees if exposed to certain issues, allowing the other trees to put up a better defense.
Ants and other insects sometimes do the same thing.
Essentially a ‘jumps on the grenade’ gene.
by lazide
12/28/2025 at 12:00:11 PM
s/egg/which/by AlecSchueler
12/28/2025 at 1:46:18 PM
You don't egg randomly inserted words?by sejje
12/28/2025 at 2:03:28 PM
eh… can someone please accurately vibe code this for me? s/(s\\\/egg\\\/which)/s\/egg\/egg which\//
by cwmoore
12/28/2025 at 6:52:08 PM
Now I want McDonalds McEggWhichby schemathings
12/28/2025 at 12:45:02 PM
the section immediately after that you didn’t quote:> evidence keeps piling up. Most recently, in November 2025, a comprehensive paper (opens a new tab) published in Cell Metabolism traced the downstream molecular effects of a father mouse’s exercise regimen on sperm microRNAs that target genes “critical for mitochondrial function and metabolic control” in a developing embryo. The researchers found many of those same RNAs overexpressed in the sperm of well-exercised human men.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(25)...
by whimsicalism
12/28/2025 at 1:23:50 PM
I and others generally don't quote things that aren't relevant to the point we're making and I'm not keen on the crypt-accusation. I didn't say that there aren't downstream molecular effects--clearly there are. Rather, the article is very unclear about the nature of epigenetics, and the wording about "transmitting traits" is misleading at best and leads to many unwarranted conclusions, as evidenced in the comments here. The statements I quoted are not about transmitting traits. e.g., "paternal exercise" refers to a trait of exercising, taking time to exercise, being motivated to exercise, etc. The "conferred benefit" of "enhanced endurance and metabolic health" is a different trait. If that is the trait being transmitted then that should be the trait being identified in male parents, not "exercise". Similarly, being exposed to nicotine is not the trait of having livers that are good at "disarming" nicotine, cocaine, and a host of other toxins ... and this is an extraordinary claim that requires extraordinary evidence, and the article provides one citation, from 2017.And as an epigeneticist says in the article, we have no idea how RNA is having the effects its having.
As I said, I'm happy to wait until we have moved beyond this early stage of research before making any radical inferences.
by jibal
12/28/2025 at 4:07:42 PM
In the “paternal exercise” case the trait isn’t the habit of exercising, it’s the metabolic changes of exercise that are (apparently) conferred to both father and offspring.by shwaj
12/29/2025 at 1:53:14 AM
You're completely missing the point that I explicitly stated. The trait that is purportedly being transmitted is metabolic changes that confer some advantage, but that's not what's being measured in the father, "exercise" is--not a word was said about fathers having better metabolic health, just that they "exercise". Which is reason to be skeptical of the claim.by jibal
12/29/2025 at 4:54:56 AM
Fair enough. It would be a clearer result (more “apples to apples”) if the same trait was directly measured “on both sides”. Thanks for restating.Edit: typo
by shwaj
12/29/2025 at 8:01:59 AM
Have you considered that checking for that specifically might not be actually needed? After all, the correlation between exercise and metabolic health is well established.by pegasus
12/29/2025 at 6:44:08 PM
That was my original thought, however if you want to quantify an effect it would be ideal to measure the same trait in both parent and offspring. I assume that the reason that this was done (I didn’t read the papers) is because this is a retrospective study, where the participants self-report on the exercise level of their fathers, rather than a longitudinal study which could measure the fathers’ metabolic state fitness at time of conception.Thus, although there is a plausible link, I now agree with the parent post that this is sufficient reason to take the study with a grain of salt (given well known academic incentives to produce positive results, etc).
by shwaj
12/28/2025 at 7:03:25 AM
Theres huge uncertainty and layered assumptions in all of microbiology and biochemistry about how exactly things work on small scale. Because it is really hard to study live reactions in little things you can just barely see on an electron microscope.But yet humanity has managed to assert statistical truths about for example genetics and explain countless diseases, even cure and alleviate some. So even if you don’t have a theory on how exactly something works from the ground up, if you have statistical evidence, plenty of useful and practical advances can be built top-bottom and we have outcomes that validate this.
Not giving any opinion on this piece specifically but just saying there can be scientific value even if the details are hand-wavy.
by yes_man
12/28/2025 at 7:12:48 AM
For an example, scientists discovered both viruses and genetics long before they knew the molecular basis of either of them.by roywiggins
12/28/2025 at 9:14:43 AM
I'm well aware of that. The point is that people are drawing all sorts of unwarranted conclusions from this lay report on early stage research.by jibal
12/28/2025 at 9:43:43 AM
> The point is that people are drawing all sorts of unwarranted conclusions from this lay report on early stage research.That is partly because no one seems willing to summarize this work, in concise form, for nonspecialists. Such a summary might be, "This is an important finding, but it doesn't mean Lysenko was right, and the term 'inheritance' doesn't have just one meaning."
I think the term "inheritance" for both DNA and epigenetic information transfers (as in the linked article) is innately confusing.
by lutusp
12/28/2025 at 9:56:35 AM
I agree. The example with Nicotine intake having a somewhat positive effect on the children feels too wild at the money. Think of all the kids of the 60th and 70th. They must be immune to most toxins ;). Yes I take this example to the extreme. I also feel that this could maybe contradict what we learned from evolution theory. Why would it take so long for a given treat to establish itself. Maybe I mix too much into one bag after reading this one article.by larusso
12/28/2025 at 10:30:29 AM
>I also feel that this could maybe contradict what we learned from evolution theory.It doesn't, but the article doesn't go into this detail, so people unfamiliar with the field wouldn't understand why. The keyword is epigenetics. I.e. how certain genes become activated or deactivated through behaviour and/or environmental influences. But the DNA sequence itself remains unaltered. So no evolution necessary. There are basically a bunch of molecules than sit on top of your DNA that regulate gene expression. They don't just tell a cell to behave like a skin cell or a brain cell, they also regulate the entire cellular metabolism. The discovery that male sperm can also transmit this epigenetic information to offspring is relatively new, but now that we know that, it makes total sense that these gene-expression-modifying behaviours in fathers could affect their children. After all, they simply get to start with a good (or bad) bunch of epigenetic markers. They will not persist across many generations though, so it has no real long term effect on evolution. It may even be an evolved mechanism that allows organisms to respond to environmental changes on timeframes that would be prohibited by evolution.
by sigmoid10
12/28/2025 at 12:49:54 PM
Not all epigenetics is regulation of gene expression. The article says "these molecules transmit traits to offspring and that they can regulate embryonic development after fertilization" -- that's from the reporter, but I don't have faith that "transmit traits" is at all accurate--it certainly isn't true in the way that genes express traits. And then they quote an actual epigeneticist saying “We just don’t have really any understanding of how RNAs can do this, and that’s the hand-wavy part”by jibal
12/28/2025 at 4:29:45 PM
>that's from the reporter, but I don't have faith that "transmit traits" is at all accurateIt is pretty accurate, even if we don't understand all details yet. Here's a review article of the current research that's not from a popsci journalist: https://www.nature.com/articles/s41467-023-37820-2
by sigmoid10
12/29/2025 at 2:00:48 AM
That does not in the least address my concern. Again, "it certainly isn't true in the way that genes express traits".by jibal
12/29/2025 at 3:28:38 PM
You may be confused by the terminology, but that is literally what the word "phenotype" in the linked article means. Just in science-lingo.by sigmoid10
12/28/2025 at 11:09:52 AM
> ”They will not persist across many generations though”Why not? Is there some tempering mechanism on epigenetic transfer? I could imagine that some sperm-conferred epigenetic markers could continue down the male descendants unbroken.
by pcl
12/29/2025 at 6:04:13 PM
If I understand both correctly, a better answer to your question than sibling post is that yes, that could be imagined, but your dichotomy is not mutually exclusive, and the process described here is much more related to variable conditions of the environment and the parents’ health at the time of conception rather than to the replicable genetic structures.by cwmoore
12/28/2025 at 12:50:42 PM
Because chromosomes in nuclei reproduce via very sophisticated and highly regulated processes; random epigenetic molecules do not.by jibal
12/28/2025 at 2:08:09 PM
Makes me wonder about how the two interact in the human phenomenon of generational oscillationsby cwmoore
12/28/2025 at 11:00:06 AM
Speaking mostly from personal experience here, if a kid gets a suped-up liver from their dad's smoking habits, cool. But how many kids fathers stopped smoking when the kid was born? My point, the father's smoking habits may have passed down a strong liver but his continued use damaged the child's lungs and possibly more.These mechanisms of epigenetic inheritance or whatever need much more study. It is far too early to draw any conclusions other than we need to keep researching.
by skinwill
12/28/2025 at 10:06:38 AM
If true, I suppose there is also a opportunity cost involved. Meaning selecting for better coping with nicotine, does not help selecting for smarter offspring and maybe even preventing that. So it might be somewhat positive but at a cost unknown.Also there are the very known costs of nicotine damaging sperms, or of course being in literal smoke as a child (or adult) and deal with those real effects.
by lukan
12/28/2025 at 11:48:33 AM
> They must be immune to most toxins ;)Allergies and cancer are way up.
There’s multiple causes behind those, this is almost certainly one.
by DANmode
12/28/2025 at 11:22:28 AM
>Think of all the kids of the 60th and 70th. They must be immune to most toxins ;).
60th and 70th what?? :)But seriously though, "immune" is a humorous exaggeration, but I'm not sure we have data to rule out the idea that this cohort has increased tolerance to some environmental toxins.
So it's possible the level of harm we see today is already "post-" this protective effect, if any.
by schiffern
12/28/2025 at 11:31:57 AM
> 60th and 70th what?? :)
GP means that from the 1960s to the 1970s many people in his part of the world were deliberately putting "toxins" in their bodies.He means that the hippie generation and disco generation took a lot of drugs.
by dotancohen
12/28/2025 at 11:37:27 AM
I figured, just a joke playing off their typo (hence the smiley).There were plenty of non-"drug" toxins people were exposed to where levels peaked around that time — leaded gasoline, early food contact plastics with unsafe additives, pesticides that are now banned, etc. But thanks Nancy Reagan. ;)
by schiffern
12/28/2025 at 11:47:15 AM
Humans put toxins into their bodies for the entire history of humankind.by vbezhenar
12/28/2025 at 11:47:14 AM
You took a left-turn:Nicotine is on-par with caffeine in isolation.
It’s the rest of the crap in smokes and vapes to be concerned with.
I was surprised to learn nicotine is used by functional doctors to treat CFS-adjacent conditions, and the mechanisms therein.
by DANmode
12/28/2025 at 12:58:07 PM
> You took a left-turnI certainly didn't; I simply quoted a sentence from the article. (I've noticed that some people have difficulty distinguishing between the person who quotes something and the person being quoted ... it might be a Sally-Anne effect.)
> It’s the rest of the crap in smokes and vapes to be concerned with.
Yes, which makes this article even less reliable.
by jibal
12/28/2025 at 7:00:19 PM
The part where you said nicotine was a bad habit seemed to be your words,an unquoted section.
You can attribute that opinion to the author, or society, or whoever now, if you choose,
regardless my point remains: nicotine shouldn’t be filed under “bad habit” by default.
by DANmode
12/29/2025 at 1:55:49 AM
> The part where you said nicotine was a bad habit seemed to be your wordsSeriously?
I can't take this as anything other than bad faith.
by jibal
12/28/2025 at 12:48:08 PM
nicotine is significantly more harmful than caffeine, although it is definitely way better than the other stuff in tobacco and not a carcinogen.let’s not get started on the CFS stuff, treatments for functional disorders are often placebo-resembling.
by whimsicalism
12/28/2025 at 3:00:51 PM
> nicotine is significantly more harmful than caffeine“Significantly” is an opinion.
It’s more toxic by weight, yes.
Messes with vascular more than caffeine.
Both are an excellent way to screw up heart health.
> let’s not get started on the CFS stuff, treatments for functional disorders are often placebo-resembling.
Personally haven’t needed or wanted to use nicotine, but I have recovered from an array of chronic illnesses; I’ll get started on anything I please, thanks,
especially seeing how many of my peers are hopelessly exhausted and existing on abusive amounts of caffeine/prescription stimulants to get by.
by DANmode
12/28/2025 at 7:56:13 PM
> Both are an excellent way to screw up heart health.Plain black coffee has, somewhat surprisingly, been repeatedly demonstrated to be very healthy - with substantial reductions in all-cause mortality as well as the chances of developing cardiovascular disease. I tend to live somewhat spartanly in terms of consumption, and wanted to drop my coffee habit which looks something like this [1], but looking up the data on it left me dropping that idea real fast.
by somenameforme
12/28/2025 at 9:40:27 PM
Coffee ≠ caffeine, despite the coy conflations in office memes.If you’re grinding your own (mycotoxins are real), hard to find a cleaner healthier form of caffeine than coffee!
Lots of morning-and-day soda and energy drink consumers. More than we even see, assuredly.
by DANmode
12/28/2025 at 3:18:05 PM
[flagged]by whimsicalism
12/28/2025 at 7:04:42 PM
Off-topic completely now,but for your information, one last question:
does your opinion cover patents who have blood test results showing Lyme, and one or more known coinfections like Bab, Bart, (all known, and treatable bacterial infections),
or are you another Reddit regurgitation expert?
by DANmode
12/28/2025 at 8:29:23 PM
i think this isn’t going to be a productive conversation regardless of what i say. take careby whimsicalism
12/28/2025 at 8:35:51 PM
We’re on the same page.by DANmode
12/28/2025 at 12:06:54 PM
Also “mouse models”.The only purpose mouse models serve is to fill the popular press with sensational findings and torture a lot of mice.
by hshdhdhj4444
12/28/2025 at 12:42:49 PM
the only purpose of hacker news comments is to aggravate readers with overly reductive takesby whimsicalism
12/29/2025 at 6:05:35 PM
Thanks, both of you, now please stop it.by cwmoore
12/28/2025 at 7:06:32 PM
They’re mice. I wouldn’t worry a whole lot about them.by Vaslo
12/28/2025 at 12:38:27 PM
For this particular research, it's possible as only 5% of mouse experiments become available to humans.But a lot of life-saving medicaments and techniques started as mouse testings, including Penicillin, cancer drugs and the polio vaccine.
by oceansky
12/28/2025 at 11:48:14 AM
although it's like milk too. exposure at an early age leads to the body producing more lactase enzyme to digest it. but lack of exposure often makes people lactose intolerant.by didntknowyou
12/28/2025 at 5:31:46 PM
I feel like the ghost of Lysenko is laughing at us.by RobotToaster