Very often I find myself wanting to store item(s) using a key.My items are not relations, and I don't see the point in transforming them to and from relational form. And if I did, each row would have like 5 columns set to NULL, in addition to a catch-all string 'data' column where I put the actual stuff I really need. Which is how you slow down an SQL database. So RDBMS is no good for me, and I'm no good for RDBMS.
RDBMS offers strong single-node consistency guarantees (which people leave off by default by using an isolation level of 'almost'!). But even without microservices, there are too many nodes: the DB, the backend, external partner integrations, the frontend, the customer's brain. You can't do if-this-then-that from the frontend, since 'this' will no longer be true when 'that' happens. So even if I happen to have a fully-ACID DB, I still lean into events & eventual consistency to manage state across the various nodes.
Given that I'm using more data than a naive CRUD/SQL app would (by storing events for state replication) and my data is stringy enough to kill my (and others') performance. So what's the solution? Make my read-writes completely independent from other read-writes - no joins, no foreign keys, etc.
The thing that would put me off using DynamoDB is the same reason I wouldn't use any other tech - can I download it? For this reason I'd probably reach for Cassandra first. That said I haven't looked at the landscape in a while and there might be much better tools.
But it also wouldn't matter what I want to use instead of DynamoDB, because the DevOps team of wherever I work will just choose whatever's native&managed by their chosen cloud provider.